US Study Uncovers 275 Million Entirely New Genetic Variants

In a National Institutes of Health-funded study, researchers have made a discovery within the genetic code of 250,000 U.S. volunteers, uncovering more than 275 million previously unidentified variants that could illuminate why certain diseases are more prevalent in specific groups. This significant leap in genomic research, part of the “All of Us” initiative, aims to bring diversity to the forefront by including genetic data from historically underrepresented communities, challenging the existing Euro-centric genomic databases.  

The study revealed a billion genetic variants and identified nearly 4 million differences potentially linked to disease risk, shedding light on the vast genetic landscape that influences health disparities. Dr. Josh Denny, a key figure in the study, highlighted the potential of these findings to pave the way for new, inclusive drug targets and tailored treatments that address the unique disease burdens diverse populations face. This research marks a pivotal step towards understanding the complex interplay between genetics and disease, aspiring to encompass DNA and health data from a million people to refine disease risk assessments and foster the development of more effective prevention strategies and therapies for all, regardless of their ancestry. The initiative starkly addresses the critical need for inclusivity in genetic research, given that nearly 90% of genomic studies have historically focused on individuals of European descent, thus limiting the scope of medical advancements. With these new insights, scientists will explore the implications of genetic diversity on health, potentially revolutionizing personalized medicine and public health strategies. 

US Study Uncovers 275 Million Entirely New Genetic Variants (Steenhuysen, Reuters,2/19). 


Categories: PulsePublished On: February 22nd, 2024Tags: , ,


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